COVID-19 deaths in the United States have topped 800,000, with more than 25% of fatalities coming after vaccines became available earlier this year.
The number of deaths hit what President Joe Biden called a “tragic milestone” on Tuesday, according to data compiled by Johns Hopkins University.
The overall death toll is roughly equal to the population of Atlanta and St Louis combined – or Minneapolis and Cleveland put together.
It is also roughly equivalent to how many Americans die each year from heart disease or stroke.
The US also has the highest reported toll of any country, accounting for approximately 4% of the world’s population but about 15% of the 5.3 million known deaths from COVID-19 since the pandemic began.
The true number of deaths in the US and around the world is believed to significantly higher because of cases that were overlooked or concealed.
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A closely watched forecasting model from the University of Washington projects a total of more than 880,000 reported deaths in the US by March.
Mr Biden on Tuesday reiterated calls for unvaccinated Americans to get jabs for themselves and their children and urged the vaccinated to get booster shots.
He said: “I urge all Americans: do your patriotic duty to keep our country safe, to protect yourself and those around you, and to honour the memory of all those we have lost.
“Now is the time.”
Health experts also lamented the number of deaths, saying many were especially heartbreaking because they were preventable by way of the vaccine, which became available around a year ago and was thrown open to all adults by mid-April.
Around 200 million Americans are fully vaccinated – or just over 60% of the population, which is well short of what scientists say is needed to keep the virus in check.
“Almost all the people dying are now dying preventable deaths,” said Dr Chris Beyrer, an epidemiologist at the Johns Hopkins Bloomberg School of Public Health.
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“And that’s because they’re not immunised. And you know that, God, it’s a terrible tragedy.”
When the vaccine was first rolled out, the country’s death toll stood at about 300,000. It hit 600,000 in mid-June and 700,000 on 1 October.
The US crossed the latest threshold with cases and hospitalisations on the rise again in a spike driven by the highly contagious Delta variant, which arrived in the first half of 2021 and now accounts for practically all infections.
Now the Omicron variant is gaining a foothold in the country.
Dr Beyrer recalled that in March or April 2020, one of the worst-case scenarios projected upwards of 240,000 American deaths.
“And I saw that number, and I thought that is incredible – 240,000 American deaths?” he said. “We’re now past three times that number.”
“I think it’s fair to say that we’re still not out of the woods.”